Reconstituting the kinetochore–microtubule interface: what, why, and how.

Journal article

The kinetochore is the proteinaceous complex that governs the movement of duplicated chromosomes by interacting with spindle microtubules during mitosis and meiosis. Faithful chromosome segregation requires that kinetochores form robust load-bearing attachments to the tips of dynamic spindle microtubules, correct microtubule attachment errors, and delay the onset of anaphase until all chromosomes have made proper attachments. To understand how this macromolecular machine operates to segregate...

Expand abstract

Authors: Akiyoshi, B; Biggins, S

• Journal: Chromosoma
• Volume: 121
• Issue: 3
• Pages: 235-250
• Publication date: 2012-06-01
• DOI: 10.1007/s00412-012-0362-0
• EISSN: 1432-0886
• ISSN: 0009-5915
• Language: English
• Keywords: Animals; Caenorhabditis elegans Proteins; Aurora Kinases; Microtubules; Saccharomycetales; Histones; Phosphorylation; Ultracentrifugation; Microtubule-Associated Proteins; Protein-Serine-Threonine Kinases; Kinetochores; Chromosome Segregation; Cell Fractionation