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Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei.

Abstract:

The large-scale chromatin organization of the major histocompatibility complex and other regions of chromosome 6 was studied by three-dimensional image analysis in human cell types with major differences in transcriptional activity. Entire gene clusters were visualized by fluorescence in situ hybridization with multiple locus-specific probes. Individual genomic regions showed distinct configurations in relation to the chromosome 6 terrritory. Large chromatin loops containing several megabases...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Journal of cell science More from this journal
Volume:
113 ( Pt 9)
Issue:
9
Pages:
1565-1576
Publication date:
2000-05-01
EISSN:
1477-9137
ISSN:
0021-9533
Language:
English
Keywords:
Pubs id:
pubs:31652
UUID:
uuid:61fdb681-ebdb-4852-b490-d4d1e98a9ebf
Local pid:
pubs:31652
Source identifiers:
31652
Deposit date:
2012-12-19

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