Journal article icon

Journal article

Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy.

Abstract:

New inhibitors are urgently needed to overcome the burgeoning problem of drug resistance in the treatment of Plasmodium falciparum infection. Targeting the folate pathway has proved to be a powerful strategy for drug development against rapidly multiplying systems such as cancer cells and microorganisms. Antifolates have long been used for malaria treatment but, despite their success, much less is known about parasite folate metabolism than about that of the human host. In this article, we fo...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.pt.2005.04.002

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
Trends in parasitology More from this journal
Volume:
21
Issue:
6
Pages:
292-298
Publication date:
2005-06-01
DOI:
EISSN:
1471-5007
ISSN:
1471-4922
Language:
English
Keywords:
Pubs id:
pubs:39546
UUID:
uuid:61ddd795-704d-4db8-afc9-7528cc5eeb9f
Local pid:
pubs:39546
Source identifiers:
39546
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP