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Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.

Abstract:

Meta-analyses of population-based genome-wide association studies (GWAS) in adults have recently led to the detection of new genetic loci for obesity. Here we aimed to discover additional obesity loci in extremely obese children and adolescents. We also investigated if these results generalize by estimating the effects of these obesity loci in adults and in population-based samples including both children and adults. We jointly analysed two GWAS of 2,258 individuals and followed-up the best, ...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pgen.1000916

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Journal:
PLoS genetics
Volume:
6
Issue:
4
Pages:
e1000916
Publication date:
2010-04-01
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Source identifiers:
54834
Language:
English
Keywords:
Pubs id:
pubs:54834
UUID:
uuid:61d7988e-5e89-4118-97bd-9bb865e4ab75
Local pid:
pubs:54834
Deposit date:
2012-12-19

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