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Brain glutamate in medication-free depressed patients: A proton MRS study at 7 Tesla

Abstract:

Background: The possible role of glutamate in the pathophysiology and treatment of depression is of intense current interest. Proton magnetic resonance spectroscopy (MRS) enables the detection of glutamate in the living human brain and meta-analyses of previous MRS studies in depressed patients have suggested that glutamate levels are decreased in anterior brain regions. Nevertheless, at conventional magnetic field strengths (1.5- 3 Tesla), it is difficult to separate glutamate from its me...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1017/S0033291717003373

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More from this funder
Funding agency for:
Cowen, P
Grant:
MR/K022202/1
Publisher:
Cambridge University Press Publisher's website
Journal:
Psychological Medicine Journal website
Volume:
48
Pages:
1731-1737
Publication date:
2017-12-11
Acceptance date:
2017-10-24
DOI:
EISSN:
1469-8978
ISSN:
0033-2917
Pubs id:
pubs:744106
UUID:
uuid:61d5cc85-4f32-4b1b-bb2d-4a02a1b643d2
Local pid:
pubs:744106
Source identifiers:
744106
Deposit date:
2017-11-09

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