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Mitophagy plays a central role in mitochondrial ageing

Abstract:

The mechanisms underlying ageing have been discussed for decades, and advances in molecular and cell biology of the last three decades have accelerated research in this area. Over this period, it has become clear that mitochondrial function, which plays a major role in many cellular pathways from ATP production to nuclear gene expression and epigenetics alterations, declines with age. The emerging concepts suggest novel mechanisms, involving mtDNA quality, mitochondrial dynamics or mitochondr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00335-016-9651-x

Authors


Diot, Alan More by this author
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Department:
Oxford, MSD, Obstetrics & Gynaecology
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Department:
Default/Not Applicable
Lily Foundation More from this funder
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Grant:
(SG/14-15/11)
Angus Memorial Mitochondrial Fund More from this funder
Publisher:
Springer Verlag Publisher's website
Journal:
Mammalian Genome Journal website
Issue:
7-8
Publication date:
2016-06-28
DOI:
ISSN:
0938-8990 and 1432-1777
Pubs id:
pubs:631063
URN:
uri:61d50466-fbdf-4d31-a64d-f37d2c5948e4
UUID:
61d50466-fbdf-4d31-a64d-f37d2c5948e4
Local pid:
pubs:631063
Language:
English
Keywords:

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