Journal article
Mitophagy plays a central role in mitochondrial ageing
- Abstract:
- The mechanisms underlying ageing have been discussed for decades, and advances in molecular and cell biology of the last three decades have accelerated research in this area. Over this period, it has become clear that mitochondrial function, which plays a major role in many cellular pathways from ATP production to nuclear gene expression and epigenetics alterations, declines with age. The emerging concepts suggest novel mechanisms, involving mtDNA quality, mitochondrial dynamics or mitochondrial quality control. In this review, we discuss the impact of mitochondria in the ageing process, the role of mitochondria in reactive oxygen species production, in nuclear gene expression, the accumulation of mtDNA damage and the importance of mitochondrial dynamics and recycling. Declining mitophagy (mitochondrial quality control) may be an important component of human ageing.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 891.5KB, Terms of use)
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- Publisher copy:
- 10.1007/s00335-016-9651-x
Authors
- Publisher:
- Springer Verlag
- Journal:
- Mammalian Genome More from this journal
- Issue:
- 7-8
- Publication date:
- 2016-06-28
- Acceptance date:
- 2016-05-24
- DOI:
- ISSN:
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1432-1777 and 0938-8990
Terms of use
- Copyright holder:
- Diot, Morten and Poulton
- Copyright date:
- 2016
- Notes:
- The Author(s) 2016. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
- Licence:
- CC Attribution (CC BY)
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