Adenovirus-mediated gene transfer of a secreted form of human macrophage scavenger receptor inhibits modified low-density lipoprotein degradation and foam-cell formation in macrophages.

Journal article

BACKGROUND: Macrophage scavenger receptors (MSRs) play an important role in the pathogenesis of atherosclerosis. Therefore, local modulation of MSR activity could have a beneficial effect on atherogenesis. METHODS AND RESULTS: We cloned a secreted "decoy" MSR (sMSR) that contains an extracellular portion of the human MSR type AI and constructed an adenoviral vector that directs high-level expression of sMSR in macrophages under the control of the human CD68 promoter. Expression of the sMSR pr...

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Authors: Laukkanen, J; Lehtolainen, P; Gough, P; Greaves, D; Gordon, S

• Publication status: Published
• Journal: Circulation
• Volume: 101
• Issue: 10
• Pages: 1091-1096
• Publication date: 2000-03-01
• DOI: 10.1161/01.cir.101.10.1091
• EISSN: 1524-4539
• ISSN: 0009-7322
• Language: English
• Keywords: Foam Cells; Adenoviridae; Macrophages; Genetic Vectors; Humans; Lipoproteins, LDL; Gene Transfer Techniques; Receptors, Scavenger; Animals; Receptors, Immunologic; Recombinant Fusion Proteins; Mice