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Adenovirus-mediated gene transfer of a secreted form of human macrophage scavenger receptor inhibits modified low-density lipoprotein degradation and foam-cell formation in macrophages.

Abstract:

BACKGROUND: Macrophage scavenger receptors (MSRs) play an important role in the pathogenesis of atherosclerosis. Therefore, local modulation of MSR activity could have a beneficial effect on atherogenesis. METHODS AND RESULTS: We cloned a secreted "decoy" MSR (sMSR) that contains an extracellular portion of the human MSR type AI and constructed an adenoviral vector that directs high-level expression of sMSR in macrophages under the control of the human CD68 promoter. Expression of the sMSR pr...

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Publication status:
Published

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Publisher copy:
10.1161/01.cir.101.10.1091

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Circulation More from this journal
Volume:
101
Issue:
10
Pages:
1091-1096
Publication date:
2000-03-01
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
Language:
English
Keywords:
Pubs id:
pubs:30128
UUID:
uuid:61d156b9-d6ac-4917-844f-998d40d6207b
Local pid:
pubs:30128
Source identifiers:
30128
Deposit date:
2012-12-19

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