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Self-stimulation at the lateral hypothalamus and locus coeruleus after specific unilateral lesions of the dopamine system.

Abstract:

A group of rats was trained to press levers for electrical stimulation from bipolar electrodes aimed at the lateral hypothalamus (LH), and another group was trained to self-stimulate from electrodes in the locus coeruleus (LC). All rats in both groups were subjected to unilateral injections of 6-hydroxydopamine into the substantia nigra and midbrain ventral tegmentum. The lesions produced profound depletions of dopamine from the ipsilateral frontal cortex, nucleus accumbens/olfactory tubercle...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Brain research
Volume:
146
Issue:
1
Pages:
123-140
Publication date:
1978-05-05
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
URN:
uuid:61cf827b-f453-4f9d-bc35-b358a79afdb7
Source identifiers:
6369
Local pid:
pubs:6369

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