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Journal article

Thalamic neurodegeneration in multiple sclerosis.

Abstract:

Multiple sclerosis is still regarded primarily as a disease of the white matter. However, recent evidence suggests that there may be significant involvement of gray matter. Here, we have used magnetic resonance imaging and magnetic resonance spectroscopy in vivo and histopathology postmortem to estimate thalamic neuronal loss in patients with multiple sclerosis. Our results show that neuronal loss in multiple sclerosis can be substantial (30-35% reduction). We conclude that a neurodegenerativ...

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Publication status:
Published

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Publisher copy:
10.1002/ana.10326

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Annals of neurology More from this journal
Volume:
52
Issue:
5
Pages:
650-653
Publication date:
2002-11-01
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
Language:
English
Keywords:
Pubs id:
pubs:241366
UUID:
uuid:61cde28f-129b-421f-9e28-4cbe87064496
Local pid:
pubs:241366
Source identifiers:
241366
Deposit date:
2012-12-19

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