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The conductance of red blood cells from sickle cell patients: ion selectivity and inhibitors

Abstract:

The abnormally high cation permeability in red blood cells (RBCs) from patients with sickle cell disease (SCD) occupies a central role in pathogenesis. Sickle RBC properties are notably heterogeneous, however, thus limiting conventional flux techniques that necessarily average out the behaviour of millions of cells. Here we use the whole-cell patch configuration to characterise the permeability of single RBCs from patients with SCD in more detail. A non-specific cation conductance was reversi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
ORCID:
0000-0003-4046-5219
More by this author
Role:
Author
ORCID:
0000-0003-3647-1050
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Name:
Medical Research Council
Grant:
G0901177
Publisher:
Wiley
Journal:
Journal of Physiology More from this journal
Volume:
590
Issue:
9
Pages:
2095-2105
Place of publication:
England
Publication date:
2012-04-03
Acceptance date:
2012-03-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Pmid:
22411011
Language:
English
Keywords:
Pubs id:
316440
Local pid:
pubs:316440
Deposit date:
2020-04-03

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