Journal article
The conductance of red blood cells from sickle cell patients: ion selectivity and inhibitors
- Abstract:
-
The abnormally high cation permeability in red blood cells (RBCs) from patients with sickle cell disease (SCD) occupies a central role in pathogenesis. Sickle RBC properties are notably heterogeneous, however, thus limiting conventional flux techniques that necessarily average out the behaviour of millions of cells. Here we use the whole-cell patch configuration to characterise the permeability of single RBCs from patients with SCD in more detail. A non-specific cation conductance was reversi...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Journal of Physiology Journal website
- Volume:
- 590
- Issue:
- 9
- Pages:
- 2095-2105
- Place of publication:
- England
- Publication date:
- 2012-04-03
- Acceptance date:
- 2012-03-05
- DOI:
- EISSN:
-
1469-7793
- ISSN:
-
0022-3751
- Pmid:
-
22411011
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
316440
- Local pid:
- pubs:316440
- Deposit date:
- 2020-04-03
Terms of use
- Copyright holder:
- Ma et al.
- Copyright date:
- 2012
- Rights statement:
- © 2012 The Authors. The Journal of Physiology © 2012 The Physiological Society
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