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Pharmacokinetics and anticonvulsant effects of diazepam in children with severe falciparum malaria and convulsions.

Abstract:

AIMS: Convulsions are a common complication of severe malaria in children and are associated with poor outcome. Diazepam is used to terminate convulsions but its pharmacokinetics and pharmacodynamics have not been studied in this group. Accordingly, we carried out a comparative study of the pharmacokinetics of intravenous (i.v.) and rectal (p.r.) diazepam. METHODS: Twenty-five children with severe malaria and a convulsion lasting >5 min were studied. Sixteen children received diazepam int...

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Publication status:
Published

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Journal:
British journal of clinical pharmacology
Volume:
53
Issue:
1
Pages:
49-57
Publication date:
2002-01-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:61c6bfd1-c1c5-49b4-8e89-e6c0a4c19c76
Source identifiers:
38118
Local pid:
pubs:38118

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