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Gating deficits in model networks: a path to schizophrenia?

Abstract:
Gating deficits and hallucinatory sensations are prominent symptoms of schizophrenia. Comparing these abnormalities with the failure modes of network models is an interesting way to explore how they arise. We present a network model that can both propagate and gate signals. The model exhibits effects reminiscent of clinically observed pathologies when the balance between excitation and inhibition that it requires is not properly maintained.
Publication status:
Published

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Publisher copy:
10.1055/s-2007-992130

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Pharmacopsychiatry More from this journal
Volume:
40 Suppl 1
Issue:
S 1
Pages:
S73-S77
Publication date:
2007-12-01
DOI:
EISSN:
1439-0795
ISSN:
0176-3679
Language:
English
Keywords:
Pubs id:
pubs:401640
UUID:
uuid:61bc825d-1619-49a8-81a2-f36ec1f6968c
Local pid:
pubs:401640
Source identifiers:
401640
Deposit date:
2013-11-16

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