Journal article
Haemodynamics regulate fibronectin assembly via PECAM
- Abstract:
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Fibronectin (FN) assembly and fibrillogenesis are critically important in both development and the adult organism, but their importance in vascular functions is not fully understood. Here we identify a novel pathway by which haemodynamic forces regulate FN assembly and fibrillogenesis during vascular remodelling. Induction of disturbed shear stress in vivo and in vitro resulted in complex FN fibril assembly that was dependent on the mechanosensor PECAM. Loss of PECAM also inhibited the cell-i...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 1002.5KB)
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- Publisher copy:
- 10.1038/srep41223
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Authors
Funding
+ National Institutes of Health
More from this funder
Funding agency for:
Givens, C
Grant:
T32 HL069768
+ Wellcome Trust Senior Fellowship
More from this funder
Funding agency for:
Tzima, E
Grant:
HL117256
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 7
- Pages:
- 41223
- Publication date:
- 2017-01-25
- Acceptance date:
- 2016-12-13
- DOI:
- ISSN:
-
2045-2322
- Source identifiers:
-
673432
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:673432
- UUID:
-
uuid:61bbb063-6531-43b8-a6b3-fcfa77ad2fb7
- Local pid:
- pubs:673432
- Deposit date:
- 2017-01-31
Terms of use
- Copyright holder:
- © Chen, et al 2017
- Copyright date:
- 2017
- Notes:
-
© Chen, et al. 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images
or other third party material in this article are included in the article’s Creative Commons license,
unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material. To view a copy of this
license, visit http://creativecommons.org/licenses/by/4.0/
- Licence:
- CC Attribution (CC BY)
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