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Haemodynamics regulate fibronectin assembly via PECAM

Abstract:

Fibronectin (FN) assembly and fibrillogenesis are critically important in both development and the adult organism, but their importance in vascular functions is not fully understood. Here we identify a novel pathway by which haemodynamic forces regulate FN assembly and fibrillogenesis during vascular remodelling. Induction of disturbed shear stress in vivo and in vitro resulted in complex FN fibril assembly that was dependent on the mechanosensor PECAM. Loss of PECAM also inhibited the cell-i...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep41223

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More from this funder
Funding agency for:
Givens, C
Grant:
T32 HL069768
More from this funder
Funding agency for:
Tzima, E
Grant:
HL117256
More from this funder
Funding agency for:
Tzima, E
Grant:
HL117256
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
41223
Publication date:
2017-01-25
Acceptance date:
2016-12-13
DOI:
ISSN:
2045-2322
Source identifiers:
673432
Language:
English
Keywords:
Pubs id:
pubs:673432
UUID:
uuid:61bbb063-6531-43b8-a6b3-fcfa77ad2fb7
Local pid:
pubs:673432
Deposit date:
2017-01-31

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