An update on primary sclerosing cholangitis.

Journal article

PURPOSE OF REVIEW: Primary sclerosing cholangitis is a chronic cholestatic liver disease characterized by strictures of the biliary tree complicated by cirrhosis and cholangiocarcinoma. It is immune mediated, although the precise aetiology remains unknown. RECENT FINDINGS: The research into aetiology, genetic associations, pathogenesis, epidemiology, diagnosis of cholangiocarcinoma and medical treatments are discussed. SUMMARY: Multiple gene polymorphisms and human leucocyte antigen haplotyp...

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Authors: Maggs, JR; Chapman, R

• Publication status: Published
• Journal: Current opinion in gastroenterology
• Volume: 24
• Issue: 3
• Pages: 377-383
• Publication date: 2008-05-01
• DOI: 10.1097/mog.0b013e3282f9e239
• EISSN: 1531-7056
• ISSN: 0267-1379
• Language: English
• Keywords: Polymorphism, Genetic; Humans; Cholangiocarcinoma; Liver Neoplasms; Cholangitis, Sclerosing; Mutation; Genetic Predisposition to Disease