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Thesis

Versatile synthetic strategies towards the development of novel neuroblastoma inhibitors and their analogues

Abstract:

The aim of this thesis was to identify and develop anti-neuroblastoma agents via two strategies. The first involves a targeted therapy approach towards the synthesis of new drug-like PTP inhibitors (Chapter 2 and 3) and the second involved devising a new versatile synthetic route to the recently established anti-tumour natural-product lead, methyl jasmonates and its analogues (Chapter 4).

From a unique proprietary screening library of 5000 drug-like compounds targeted towards PTPs, ...

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Institution:
University of Oxford
Oxford college:
St Cross College
Department:
Mathematical,Physical & Life Sciences Division

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Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:61ab7c50-6f19-48c3-b604-91cb77d024e0
Local pid:
ora:7210

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