Expression of immune responsive genes in cell lines from two different Anopheline species.

Journal article

Malaria infection results in increased expression of immune responsive genes, including those encoding antimicrobial peptides such as Gambicin (Gam1) and Cecropin A (Cec1). Understanding how these genes are regulated will provide insights how the mosquito immune system is activated by Plasmodium. We previously have shown that Cec1 was primarily regulated by the Imd-Relish (REL2) pathway in the Anopheles gambiae Sua1B cell line. We show here that expression of Defensin A (Def1) and Gam1 was re...

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Authors: Luna, C; Hoa, N; Lin, H; Zhang, L; Nguyen, H

• Journal: Insect molecular biology
• Volume: 15
• Issue: 6
• Pages: 721-729
• Publication date: 2006-12-01
• DOI: 10.1111/j.1365-2583.2006.00661.x
• EISSN: 1365-2583
• ISSN: 0962-1075
• Language: English
• Keywords: Cell Line; Insect Proteins; Antimicrobial Cationic Peptides; Anopheles; RNA Interference; Escherichia coli; Genes, Reporter; Promoter Regions, Genetic; Immunity; Signal Transduction; Animals