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Journal article

Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase.

Abstract:

5'-O-Trityl derivatives of thymidine (dThd), (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), and their acyclic analogs 1-[(Z)-4-triphenylmethoxy-2-butenyl]thymine (KIN-12) and (E)-5-(2-bromovinyl)-1-[(Z)-4-triphenylmethoxy-2-butenyl]uracil (KIN-52) have been synthesized and evaluated for their inhibitory activity against the amino acid sequence related mitochondrial dThd kinase (TK-2), herpes simplex virus type 1 (HSV-1) TK, and Drosophila melanogaster multifunctional 2'-deoxynucleoside kinase (...

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Publication status:
Published

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Publisher copy:
10.1124/mol.63.2.263

Authors


Balzarini, J More by this author
Hernández, AI More by this author
Karlsson, A More by this author
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Journal:
Molecular pharmacology
Volume:
63
Issue:
2
Pages:
263-270
Publication date:
2003-02-05
DOI:
EISSN:
1521-0111
ISSN:
0026-895X
URN:
uuid:61a453d8-dd7f-453f-b29b-8cae29a5902e
Source identifiers:
21111
Local pid:
pubs:21111

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