In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection.

Journal article

Human T-lymphotropic virus type 1 (HTLV-1) is a persistent CD4+ T-lymphotropic retrovirus. Most HTLV-1-infected individuals remain asymptomatic, but a proportion develop adult T cell leukemia or inflammatory disease. It is not fully understood how HTLV-1 persists despite a strong immune response or what determines the risk of HTLV-1-associated diseases. Until recently, it has been difficult to quantify lymphocyte kinetics in humans in vivo. Here, we used deuterated glucose labeling to quantif...

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Authors: Asquith, B; Zhang, Y; Mosley, A; de Lara, C; Wallace, D

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 104
• Issue: 19
• Pages: 8035-8040
• Publication date: 2007-05-01
• DOI: 10.1073/pnas.0608832104
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Humans; T-Lymphocytes; Cell Division; T-Lymphocytes, Cytotoxic; HTLV-I Infections; Antigens, CD45; Lymphocyte Activation; Gene Products, tax; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Paraparesis, Tropical Spastic