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In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection.

Abstract:

Human T-lymphotropic virus type 1 (HTLV-1) is a persistent CD4+ T-lymphotropic retrovirus. Most HTLV-1-infected individuals remain asymptomatic, but a proportion develop adult T cell leukemia or inflammatory disease. It is not fully understood how HTLV-1 persists despite a strong immune response or what determines the risk of HTLV-1-associated diseases. Until recently, it has been difficult to quantify lymphocyte kinetics in humans in vivo. Here, we used deuterated glucose labeling to quantif...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0608832104

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Journal:
Proceedings of the National Academy of Sciences of the United States of America More from this journal
Volume:
104
Issue:
19
Pages:
8035-8040
Publication date:
2007-05-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Language:
English
Keywords:
Pubs id:
pubs:33846
UUID:
uuid:61a219ff-cd89-4d26-b2df-8dad06a226d3
Local pid:
pubs:33846
Source identifiers:
33846
Deposit date:
2012-12-19

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