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Journal article

Cetuximab retargeting of adenovirus via the epidermal growth factor receptor for treatment of intraperitoneal ovarian cancer.

Abstract:

Gene and virotherapy of ovarian cancer, using type 5 adenovirus (Ad5), has demonstrated good activity in preclinical animal studies, particularly after intraperitoneal administration of virus; however, success in clinical trials has been limited by poor infectivity of ovarian cancer cells and inflammatory responses to Ad5. We previously demonstrated that covalent modification of Ad5 with reactive copolymers on the basis of poly(hydroxypropylmethacrylamide) can shield the virus, offering prote...

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Publication status:
Published

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Publisher copy:
10.1089/hum.2008.167

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Journal:
Human gene therapy
Volume:
20
Issue:
3
Pages:
239-251
Publication date:
2009-03-05
DOI:
EISSN:
1557-7422
ISSN:
1043-0342
URN:
uuid:619ed3b6-42e1-4556-8439-7a3d5088e595
Source identifiers:
178812
Local pid:
pubs:178812

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