- Abstract:
-
Gene and virotherapy of ovarian cancer, using type 5 adenovirus (Ad5), has demonstrated good activity in preclinical animal studies, particularly after intraperitoneal administration of virus; however, success in clinical trials has been limited by poor infectivity of ovarian cancer cells and inflammatory responses to Ad5. We previously demonstrated that covalent modification of Ad5 with reactive copolymers on the basis of poly(hydroxypropylmethacrylamide) can shield the virus, offering prote...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1089/hum.2008.167
-
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- Journal:
- Human gene therapy
- Volume:
- 20
- Issue:
- 3
- Pages:
- 239-251
- Publication date:
- 2009-03-05
- DOI:
- EISSN:
-
1557-7422
- ISSN:
-
1043-0342
- URN:
-
uuid:619ed3b6-42e1-4556-8439-7a3d5088e595
- Source identifiers:
-
178812
- Local pid:
- pubs:178812
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Cetuximab retargeting of adenovirus via the epidermal growth factor receptor for treatment of intraperitoneal ovarian cancer.
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