Journal article
Cetuximab retargeting of adenovirus via the epidermal growth factor receptor for treatment of intraperitoneal ovarian cancer.
- Abstract:
-
Gene and virotherapy of ovarian cancer, using type 5 adenovirus (Ad5), has demonstrated good activity in preclinical animal studies, particularly after intraperitoneal administration of virus; however, success in clinical trials has been limited by poor infectivity of ovarian cancer cells and inflammatory responses to Ad5. We previously demonstrated that covalent modification of Ad5 with reactive copolymers on the basis of poly(hydroxypropylmethacrylamide) can shield the virus, offering prote...
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- Publication status:
- Published
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- Publisher copy:
- 10.1089/hum.2008.167
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Authors
Bibliographic Details
- Journal:
- Human gene therapy
- Volume:
- 20
- Issue:
- 3
- Pages:
- 239-251
- Publication date:
- 2009-03-01
- DOI:
- EISSN:
-
1557-7422
- ISSN:
-
1043-0342
- Source identifiers:
-
178812
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:178812
- UUID:
-
uuid:619ed3b6-42e1-4556-8439-7a3d5088e595
- Local pid:
- pubs:178812
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2009
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