Costimulation blockade: current perspectives and implications for therapy.

Journal article

T cells must be activated before they can elicit damage to allografts, through interaction of their T cell receptor (TCR) with peptide-MHC complex and through accessory molecules. Signaling through accessory molecules or costimulatory molecules is a critical way for the immune system to fine tune T cell activation. An emerging therapeutic strategy is to target selective molecules involved in the process of T cell activation using biologic agents, which do not impact TCR signaling, thus only m...

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Authors: Kinnear, G; Jones, N; Wood, K

• Publication status: Published
• Journal: Transplantation
• Volume: 95
• Issue: 4
• Pages: 527-535
• Publication date: 2013-02-01
• DOI: 10.1097/TP.0b013e31826d4672
• EISSN: 1534-6080
• ISSN: 0041-1337
• Language: English
• Keywords: Signal Transduction; T-Lymphocytes; Transplantation Tolerance; Humans; Lymphocyte Activation; Drug Design; Organ Transplantation; Animals; Immunosuppressive Agents; Ligands; Graft Survival; Graft Rejection; Treatment Outcome; Costimulatory and Inhibitory T-Cell Receptors