Journal article icon

Journal article

The population genetics and dynamics of the thalassemias.

Abstract:

The inherited disorders of hemoglobin, including the thalassemias, are by far the commonest monogenic diseases. Although several factors are responsible for their very high frequency, the major mechanism seems to be natural selection mediated by heterozygote protection against severe forms of malaria. Recent work has highlighted the complexity of the interplay among the different hemoglobin variants themselves and among different levels of malaria resistance, and is helping to explain the ext...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.hoc.2010.08.010

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
Journal:
Hematology/oncology clinics of North America More from this journal
Volume:
24
Issue:
6
Pages:
1021-1031
Publication date:
2010-12-01
DOI:
EISSN:
1558-1977
ISSN:
0889-8588
Language:
English
Keywords:
Pubs id:
pubs:94192
UUID:
uuid:619b7639-e897-4692-a7a1-608690940cac
Local pid:
pubs:94192
Source identifiers:
94192
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP