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Journal article

Interplay between base excision repair protein XRCC1 and ALDH2 predicts overall survival in lung and liver cancer patients

Abstract:

BACKGROUND:To deliver efficacious personalised cancer treatment, it is essential to characterise the cellular metabolism as well as the genetic stability of individual tumours. In this study, we describe a new axis between DNA repair and detoxification of aldehyde derivatives with important implications for patient prognosis and treatment. METHODS:Western blot and qPCR analyses were performed in relevant non-transformed and cancer cell lines from lung and liver tissue origin in combination wi...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-9429-813X
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Name:
Medical Research Council
Grant:
MC_PC_12002
Publisher:
Springer Verlag
Journal:
Cellular Oncology More from this journal
Volume:
41
Issue:
5
Pages:
527–539
Publication date:
2018-08-02
Acceptance date:
2018-06-07
DOI:
EISSN:
2211-3436
ISSN:
2211-3428
Pmid:
30088263
Language:
English
Keywords:
Pubs id:
pubs:905011
UUID:
uuid:6193339b-4ad0-488f-9a59-4cdd4c58b9da
Local pid:
pubs:905011
Source identifiers:
905011
Deposit date:
2019-08-30

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