- Abstract:
-
Congenitally athymic rats injected with CD45RBhigh CD4+ T cells from congenic euthymic donors developed a severe wasting disease with inflammatory infiltrates in liver, lung, stomach, thyroid, and pancreas. In contrast, recipients of CD45RBlow CD4+ T cells remained well and continued to gain weight. Animals given unfractionated CD4+ T cells, i.e., a mixture of approximately two-thirds CD45RBhigh and one-third CD45RBlow, were protected from the wasting disease, and the incidence of organ-speci...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1084/jem.172.6.1701
-
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- Journal:
- The Journal of experimental medicine
- Volume:
- 172
- Issue:
- 6
- Pages:
- 1701-1708
- Publication date:
- 1990-12-05
- DOI:
- EISSN:
-
1540-9538
- ISSN:
-
0022-1007
- URN:
-
uuid:6185e321-5112-4241-ad93-8d2498b2cb6d
- Source identifiers:
-
28027
- Local pid:
- pubs:28027
- Copyright date:
- 1990
Journal article
OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.
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