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Journal article

OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset.

Abstract:

Congenitally athymic rats injected with CD45RBhigh CD4+ T cells from congenic euthymic donors developed a severe wasting disease with inflammatory infiltrates in liver, lung, stomach, thyroid, and pancreas. In contrast, recipients of CD45RBlow CD4+ T cells remained well and continued to gain weight. Animals given unfractionated CD4+ T cells, i.e., a mixture of approximately two-thirds CD45RBhigh and one-third CD45RBlow, were protected from the wasting disease, and the incidence of organ-speci...

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Publication status:
Published

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Publisher copy:
10.1084/jem.172.6.1701

Authors


Journal:
The Journal of experimental medicine
Volume:
172
Issue:
6
Pages:
1701-1708
Publication date:
1990-12-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:6185e321-5112-4241-ad93-8d2498b2cb6d
Source identifiers:
28027
Local pid:
pubs:28027

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