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A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.

Abstract:

Oxidative stress influences cell survival and homeostasis, but the mechanisms underlying the biological effects of oxidative stress remain to be elucidated. Here, we demonstrate that the protein kinase MST1 mediates oxidative-stress-induced cell death in primary mammalian neurons by directly activating the FOXO transcription factors. MST1 phosphorylates FOXO proteins at a conserved site within the forkhead domain that disrupts their interaction with 14-3-3 proteins, promotes FOXO nuclear tran...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2006.03.046

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Journal:
Cell
Volume:
125
Issue:
5
Pages:
987-1001
Publication date:
2006-06-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Source identifiers:
248011

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