Journal article
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.
- Abstract:
-
Oxidative stress influences cell survival and homeostasis, but the mechanisms underlying the biological effects of oxidative stress remain to be elucidated. Here, we demonstrate that the protein kinase MST1 mediates oxidative-stress-induced cell death in primary mammalian neurons by directly activating the FOXO transcription factors. MST1 phosphorylates FOXO proteins at a conserved site within the forkhead domain that disrupts their interaction with 14-3-3 proteins, promotes FOXO nuclear tran...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.cell.2006.03.046
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Authors
Bibliographic Details
- Journal:
- Cell
- Volume:
- 125
- Issue:
- 5
- Pages:
- 987-1001
- Publication date:
- 2006-06-01
- DOI:
- EISSN:
-
1097-4172
- ISSN:
-
0092-8674
- Source identifiers:
-
248011
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:248011
- UUID:
-
uuid:6183c051-73cd-4752-b0e6-25945471520c
- Local pid:
- pubs:248011
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2006
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