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Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer

Abstract:

Background:Non-muscle invasive (NMI) bladder cancer is characterised by increased expression and activating mutations of FGFR3. We have previously investigated the role of microRNAs in bladder cancer and have shown that FGFR3 is a target of miR-100. In this study, we investigated the effects of hypoxia on miR-100 and FGFR3 expression, and the link between miR-100 and FGFR3 in hypoxia.Methods:Bladder cancer cell lines were exposed to normoxic or hypoxic conditions and examined for the expressi...

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Publisher copy:
10.1038/bjc.2013.240

Authors


Ramachandran, A More by this author
Wigfield, S More by this author
McCormick, R More by this author
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Journal:
British Journal of Cancer
Volume:
109
Issue:
1
Pages:
50-59
Publication date:
2013-07-09
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:61822189-4ecb-407f-ad90-1da934ee36dc
Source identifiers:
415504
Local pid:
pubs:415504
Language:
English

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