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A tubulin alpha 8 mouse knockout model indicates a likely role in spermatogenesis but not in brain development.

Abstract:

Tubulin alpha 8 (Tuba8) is the most divergent member of the highly conserved alpha tubulin family, and uniquely lacks two key post-translational modification sites. It is abundantly expressed in testis and muscle, with lower levels in the brain. We previously identified homozygous hypomorphic TUBA8 mutations in human subjects with a polymicrogyria (PMG) syndrome, suggesting its involvement in development of the cerebral cortex. We have now generated and characterized a Tuba8 knockout mouse mo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0001-6861-359X
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
St John's College
Role:
Author

Contributors

Role:
Editor
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Name:
Wellcome Trust
Grant:
094279/Z/10/Z
Publisher:
Public Library of Science
Journal:
PloS One More from this journal
Volume:
12
Issue:
4
Pages:
e0174264
Publication date:
2017-04-01
Acceptance date:
2017-03-05
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Pmid:
28388629
Language:
English
Keywords:
Pubs id:
pubs:688865
UUID:
uuid:61820640-e9ac-4eaf-a3ab-852891831f70
Local pid:
pubs:688865
Source identifiers:
688865
Deposit date:
2018-02-16

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