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Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis.

Abstract:

Experiments were designed to test the hypothesis that chronic exposure to tumor necrosis factor alpha (TNF) alters the function of activated T lymphocytes. Pretreatment of tetanus toxoid-specific T cell clones with TNF for up to 16 d impaired rechallenge proliferative responses to antigen in a dose- and time-dependent fashion. IL-2 and PHA responses were preserved. Prolonged treatment with TNF impaired production of IL-2, IL-10, IFN gamma, TNF, and lymphotoxin (LT) following stimulation with ...

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Publication status:
Published

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Publisher copy:
10.1172/jci117394

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Journal:
Journal of clinical investigation
Volume:
94
Issue:
2
Pages:
749-760
Publication date:
1994-08-01
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Source identifiers:
481662

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