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Serum branched-chain amino acid to histidine ratio: a novel metabolomic biomarker of knee osteoarthritis.

Abstract:

OBJECTIVE: There is a pressing need to develop reliable molecular biomarkers in osteoarthritis. The aim of the study was to identify novel serum biomarkers for osteoarthritis using a metabolomics approach. METHODS: A two-stage study design was utilised. 123 knee osteoarthritis cases and 299 controls were selected from the TwinsUK cohort as a discovery sample. 76 knee osteoarthritis cases and 100 controls from the Chingford Study were used as replication. Knee osteoarthritis was defined as eit...

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Publication status:
Published

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Publisher copy:
10.1136/ard.2009.120857

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Annals of the rheumatic diseases
Volume:
69
Issue:
6
Pages:
1227-1231
Publication date:
2010-06-05
DOI:
EISSN:
1468-2060
ISSN:
0003-4967
URN:
uuid:61796675-1057-4806-8667-79bdb591cc6f
Source identifiers:
107876
Local pid:
pubs:107876

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