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SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction

Abstract:

The SARS-CoV-2 receptor, ACE2, is found on pericytes, contractile cells enwrapping capillaries that regulate brain, heart and kidney blood flow. ACE2 converts vasoconstricting angiotensin II into vasodilating angiotensin-(1-7). In brain slices from hamster, which has an ACE2 sequence similar to human ACE2, angiotensin II evoked a small pericyte-mediated capillary constriction via AT1 receptors, but evoked a large constriction when the SARS-CoV-2 receptor binding domain (RBD, original Wuhan va...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/brain/awac272

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Role:
Author
ORCID:
0000-0003-1262-9466
More by this author
Role:
Author
ORCID:
0000-0003-4627-3509
Publisher:
Oxford University Press
Journal:
Brain More from this journal
Volume:
146
Issue:
2
Pages:
727–738
Publication date:
2022-07-22
Acceptance date:
2022-07-11
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Language:
English
Keywords:
Pubs id:
1171520
Local pid:
pubs:1171520
Deposit date:
2021-05-28

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