A stochastic model for the evolution of metabolic networks with neighbor dependence.

Journal article

MOTIVATION: Most current research in network evolution focuses on networks that follow a Duplication Attachment model where the network is only allowed to grow. The evolution of metabolic networks, however, is characterized by gain as well as loss of reactions. It would be desirable to have a biologically relevant model of network evolution that could be used to calculate the likelihood of homologous metabolic networks. RESULTS: We describe metabolic network evolution as a discrete space con...

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Authors: Mithani, A; Preston, G; Hein, J

• Publication status: Published
• Journal: Bioinformatics (Oxford, England)
• Volume: 25
• Issue: 12
• Pages: 1528-1535
• Publication date: 2009-06-01
• DOI: 10.1093/bioinformatics/btp262
• EISSN: 1367-4811
• ISSN: 1367-4803
• Language: English
• Keywords: Metabolic Networks and Pathways; Algorithms; Models, Statistical; Computational Biology; Pseudomonas