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Testing candidate loci on chromosomes 1 and 6 for genetic linkage to Peutz-Jeghers' disease.

Abstract:

Peutz-Jeghers' syndrome (PJS) is a disease with autosomal dominant inheritance, which is characterised by gastrointestinal hamartomata and characteristic melanin pigmentation. Three candidate sites for a PJS locus have recently been proposed, chromosomes 1p31-p32, 6q25 and 6p11-cen. At the first of these sites, a multipoint LOD score of 4.00 had been found, strongly suggesting genetic linkage to PJS. The last two candidate sites were suggested by the chromosomal breakpoints of a patient with ...

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Journal:
Annals of human genetics
Volume:
60
Issue:
Pt 5
Pages:
377-384
Publication date:
1996-09-05
DOI:
EISSN:
1469-1809
ISSN:
0003-4800
URN:
uuid:616c9ef7-5aa0-4c3a-ac2b-8b9a615dbf54
Source identifiers:
72310
Local pid:
pubs:72310

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