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C. elegans Runx/CBFβ suppresses POP-1 TCF to convert asymmetric to proliferative division of stem cell-like seam cells

Abstract:

A correct balance between proliferative and asymmetric cell divisions underlies normal development, stem cell maintenance and tissue homeostasis. What determines whether cells undergo symmetric or asymmetric cell division is poorly understood. To gain insight into the mechanisms involved, we studied the stem cell-like seam cells in the Caenorhabditis elegans epidermis. Seam cells go through a reproducible pattern of asymmetric divisions, instructed by divergent canonical Wnt/β-catenin signali...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1242/dev.180034

Authors


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Role:
Author
ORCID:
0000-0001-6495-3482
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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Hertford College
Role:
Author
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Role:
Author
ORCID:
0000-0001-9015-7463
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Name:
Biotechnology & Biological Sciences Research Council
Grant:
BB/G018448/1
Publisher:
Company of Biologists
Journal:
Development More from this journal
Volume:
146
Publication date:
2019-11-18
Acceptance date:
2019-10-18
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
Pmid:
31740621
Language:
English
Keywords:
Pubs id:
pubs:1075321
UUID:
uuid:616a644b-1300-4ce1-8bc6-a6e56102c225
Local pid:
pubs:1075321
Source identifiers:
1075321
Deposit date:
2019-12-02

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