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Journal article

Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain.

Abstract:

Interleukin-1beta (IL-1) expression is associated with a spectrum of neuroinflammatory processes related to chronic neurodegenerative diseases. The single-bolus microinjection of IL-1 into the central nervous system (CNS) parenchyma gives rise to delayed and localized neutrophil recruitment, transient blood-brain barrier (BBB) breakdown, but no overt damage to CNS integrity. However, acute microinjections of IL-1 do not mimic the chronic IL-1 expression, which is a feature of many CNS disease...

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Publication status:
Published

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Authors


Ferrari, CC More by this author
Depino, AM More by this author
Campbell, S More by this author
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Journal:
The American journal of pathology
Volume:
165
Issue:
5
Pages:
1827-1837
Publication date:
2004-11-05
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:616915a5-f143-4c46-8cd0-694243525ca5
Source identifiers:
383103
Local pid:
pubs:383103

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