- Abstract:
-
Interleukin-1beta (IL-1) expression is associated with a spectrum of neuroinflammatory processes related to chronic neurodegenerative diseases. The single-bolus microinjection of IL-1 into the central nervous system (CNS) parenchyma gives rise to delayed and localized neutrophil recruitment, transient blood-brain barrier (BBB) breakdown, but no overt damage to CNS integrity. However, acute microinjections of IL-1 do not mimic the chronic IL-1 expression, which is a feature of many CNS disease...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0002-9440(10)63438-4
-
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- Journal:
- The American journal of pathology
- Volume:
- 165
- Issue:
- 5
- Pages:
- 1827-1837
- Publication date:
- 2004-11-05
- DOI:
- EISSN:
-
1525-2191
- ISSN:
-
0002-9440
- URN:
-
uuid:616915a5-f143-4c46-8cd0-694243525ca5
- Source identifiers:
-
383103
- Local pid:
- pubs:383103
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain.
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