Effects of short-term varenicline administration on cortisol in healthy, non-smoking adults: a randomized, double-blind, study.

Journal article

RATIONALE: Varenicline is the most effective drug for smoking cessation, but its use decreased because of reports of depressogenic side effects. However, because smoking and smoking cessation on their own are associated with depression, it remains unclear whether reported depressogenic effects are attributable to varenicline, or to smoking, and/or smoking cessation themselves. OBJECTIVES: Previously, we observed no depressogenic effects of varenicline on a psychological level. In the present ...

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Authors: Mocking, R; Wever, SA; Pflanz, C; Pringle, A; Parsons, E

• Publication status: Published
• Journal: Psychopharmacology
• Volume: 231
• Issue: 1
• Pages: 143-148
• Publication date: 2014-01-01
• DOI: 10.1007/s00213-013-3213-7
• EISSN: 1432-2072
• ISSN: 0033-3158
• Language: English
• Keywords: Saliva; Parasympathetic Nervous System; Data Interpretation, Statistical; Adult; Quinoxalines; Smoking Cessation; Male; Double-Blind Method; Young Adult; Hypothalamo-Hypophyseal System; Hydrocortisone; Humans; Adolescent; Benzazepines; Female; Pituitary-Adrenal System