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Preparation, characterisation and entrapment of a non-glycosidic threitol ceramide into liposomes for presentation to invariant natural killer T cells

Abstract:

Dendritic cells (DCs) are able to present glycolipids to invariant natural killer T (iNKT) cells in vivo. Very few compounds have been found to stimulate iNKT cells, and of these, the best characterised is the glycolipid α-galactosylceramide, which stimulates the production of large quantities of interferon-gamma (IFN-γ) and interleukin-4 (IL-4). However, αGalCer leads to overstimulation of iNKT cells. It has been demonstrated that the αGalCer analogue, threitol ceramide (ThrCer 2), successfu...

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Publisher copy:
10.1002/jps.22500

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Role:
Author
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Journal:
Journal of Pharmaceutical Sciences
Volume:
100
Issue:
7
Pages:
2724-2733
Publication date:
2011-07-05
DOI:
EISSN:
1520-6017
ISSN:
0022-3549
URN:
uuid:61614091-ce11-4a1a-a9dc-78c27554635b
Source identifiers:
149819
Local pid:
pubs:149819

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