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The double CUE domain of chromatin remodelling factor SMARCAD1

Abstract:

ATP-dependent chromatin remodellers represent a class of proteins that restructure chromatin through the action of a conserved helicase-like ATPase domain. Remodellers typically have several accessory binding domains alongside the ATPase. These confer target specificity and most commonly recognise histone post-translational modifications.

SMARCAD1 is a ubiquitous chromatin remodeller involved with DNA replication and re- pair. It binds directly to PCNA at the site of DNA replication...

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Role:
Supervisor
Role:
Supervisor
Institution:
University of Oxford
Oxford college:
Linacre College
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Division of Structural Biology
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Funding agency for:
Philip M. West
Publication date:
2012
Type of award:
DPhil
Level of award:
Doctoral
URN:
uuid:615cc567-c79c-4f4a-aed4-82bf67f8adac
Local pid:
ora:7535

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