Thesis
Investigation of ASPPs as regulators of pancreatic inflammation and tumorigenesis
- Abstract:
-
Pancreatic ductal adenocarcinoma (PDAC) is a cancer of unmet need with a 5-year survival following diagnosis of 3% with limited surgical, radiotherapy and chemotherapy treatment options. Central to PDAC tumorigenesis is acquisition of an oncogenic Kras mutation to drive acinar-to-ductal metaplasia and progression to PDAC that is potentiated by NF-kB deregulation. However, PDAC requires the additional loss of tumour suppressors such as p53, SMAD4 or p16. ASPP family members ASPP2 and iASPP ...
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Authors
Contributors
+ Lu, X
Role:
Supervisor
+ Harris, A
Role:
Supervisor
+ De Val, S
Role:
Supervisor
Funding
Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:6151d193-158b-4a5e-9777-b6b6e346cb9e
- Deposit date:
- 2018-07-04
Terms of use
- Copyright holder:
- Miller, P
- Copyright date:
- 2018
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