- Abstract:
-
Pancreatic ductal adenocarcinoma (PDAC) is a cancer of unmet need with a 5-year survival following diagnosis of 3% with limited surgical, radiotherapy and chemotherapy treatment options. Central to PDAC tumorigenesis is acquisition of an oncogenic Kras mutation to drive acinar-to-ductal metaplasia and progression to PDAC that is potentiated by NF-kB deregulation. However, PDAC requires the additional loss of tumour suppressors such as p53, SMAD4 or p16. ASPP family members ASPP2 and iASPP ...
Expand abstract - Role:
- Supervisor
- Role:
- Supervisor
- Role:
- Supervisor
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
- English
- Keywords:
- Subjects:
- Copyright date:
- 2018
Thesis
Investigation of ASPPs as regulators of pancreatic inflammation and tumorigenesis
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Authors
Contributors
+ Xin Lu
+ Adrian Harris
+ Sarah De Val
Funding
Bibliographic Details
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