Journal article
Transcriptional termination enhances protein expression in human cells.
- Abstract:
-
Transcriptional termination of mammalian RNA polymerase II (Pol II) requires a poly(A) (pA) signal and, often, a downstream terminator sequence. Termination is triggered following recognition of the pA signal by Pol II and subsequent pre-mRNA cleavage, which occurs either at the pA site or in transcripts from terminator elements. Although this process has been extensively studied, it is generally considered inconsequential to the level of gene expression. However, our results demonstrate that...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.molcel.2009.01.008
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Authors
Bibliographic Details
- Journal:
- Molecular cell
- Volume:
- 33
- Issue:
- 3
- Pages:
- 354-364
- Publication date:
- 2009-02-01
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- Source identifiers:
-
21208
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:21208
- UUID:
-
uuid:614eab73-a7f9-4850-a166-1c57b14f8e8b
- Local pid:
- pubs:21208
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2009
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