- Abstract:
-
Transcriptional termination of mammalian RNA polymerase II (Pol II) requires a poly(A) (pA) signal and, often, a downstream terminator sequence. Termination is triggered following recognition of the pA signal by Pol II and subsequent pre-mRNA cleavage, which occurs either at the pA site or in transcripts from terminator elements. Although this process has been extensively studied, it is generally considered inconsequential to the level of gene expression. However, our results demonstrate that...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.molcel.2009.01.008
-
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- Journal:
- Molecular cell
- Volume:
- 33
- Issue:
- 3
- Pages:
- 354-364
- Publication date:
- 2009-02-05
- DOI:
- EISSN:
-
1097-4164
- ISSN:
-
1097-2765
- URN:
-
uuid:614eab73-a7f9-4850-a166-1c57b14f8e8b
- Source identifiers:
-
21208
- Local pid:
- pubs:21208
- Copyright date:
- 2009
Journal article
Transcriptional termination enhances protein expression in human cells.
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