Journal article icon

Journal article

Transcriptional termination enhances protein expression in human cells.

Abstract:

Transcriptional termination of mammalian RNA polymerase II (Pol II) requires a poly(A) (pA) signal and, often, a downstream terminator sequence. Termination is triggered following recognition of the pA signal by Pol II and subsequent pre-mRNA cleavage, which occurs either at the pA site or in transcripts from terminator elements. Although this process has been extensively studied, it is generally considered inconsequential to the level of gene expression. However, our results demonstrate that...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Molecular cell
Volume:
33
Issue:
3
Pages:
354-364
Publication date:
2009-02-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:614eab73-a7f9-4850-a166-1c57b14f8e8b
Source identifiers:
21208
Local pid:
pubs:21208

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP