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Measurements of cytoplasmic free Ca2+ concentration in human pancreatic islets and insulinoma cells.

Abstract:

In human pancreatic islets an increase in the glucose concentration from 3 to 20 mM raised the free cytoplasmic Ca2+ concentration [( Ca2+]i), an effect being reversible upon withdrawal of the sugar. Depolarization with a high concentration of K+ or the sulphonylurea tolbutamide also raised [Ca2+]i. Addition of extracellular ATP produced a transient rapid rise in [Ca2+]i. Oscillations in [Ca2+]i were observed in the presence of 10 mM glucose. Insulinoma cells responded to glucose and tolbutam...

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Publication status:
Published

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Journal:
FEBS letters More from this journal
Volume:
291
Issue:
2
Pages:
310-314
Publication date:
1991-10-01
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
Language:
English
Keywords:
Pubs id:
pubs:12023
UUID:
uuid:614c82ac-a6c6-45c7-ad7b-4585729a2036
Local pid:
pubs:12023
Source identifiers:
12023
Deposit date:
2012-12-19

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