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Spectator no more, the role of the membrane in regulating ion channel function

Abstract:

A pressure gradient across a curved lipid bilayer leads to a lateral force within the bilayer. Following ground breaking work on eukaryotic ion channels, it is now known that many proteins sense this change in the lateral tension and alter their functions in response. It has been proposed that responding to pressure differentials may be one of the oldest signaling mechanisms in biology. The most well characterized mechanosensing ion channels are the bacterial ones which open when the pressure...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.sbi.2016.10.017

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
More from this funder
Name:
Royal Society
Funding agency for:
Naismith, J
Grant:
WT100209MA
More from this funder
Name:
Wellcome Trust
Funding agency for:
Naismith, J
Grant:
WT100209MA
More from this funder
Name:
Chinese National Thousand Talents Program
Funding agency for:
Naismith, J
Grant:
WT100209MA
More from this funder
Name:
Tenovus Scotland
Grant:
T15/41
More from this funder
Name:
Royal Society of Edinburgh
Funding agency for:
Pliotas, C
Publisher:
Elsevier
Journal:
Current Opinion in Structural Biology More from this journal
Volume:
45
Pages:
56-66
Publication date:
2016-12-07
DOI:
EISSN:
1879-033X
ISSN:
0959-440X
Language:
English
Keywords:
Pubs id:
pubs:699008
UUID:
uuid:6149b5d4-aea2-4ae6-a71d-5802ed9d0c46
Local pid:
pubs:699008
Source identifiers:
699008
Deposit date:
2017-07-24

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