MukB colocalizes with the oriC region and is required for organization of the two Escherichia coli chromosome arms into separate cell halves.

Journal article

The circular Escherichia coli chromosome is organized by bidirectional replication into two equal left and right arms (replichores). Each arm occupies a separate cell half, with the origin of replication (oriC) at mid-cell. E. coli MukBEF belongs to the ubiquitous family of SMC protein complexes that play key roles in chromosome organization and processing. In mukBEF mutants, viability is restricted to low temperature with production of anucleate cells, reflecting chromosome segregation defec...

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Authors: Danilova, O; Reyes-Lamothe, R; Pinskaya, M; Sherratt, D; Possoz, C

• Publication status: Published
• Journal: Molecular microbiology
• Volume: 65
• Issue: 6
• Pages: 1485-1492
• Publication date: 2007-09-01
• DOI: 10.1111/j.1365-2958.2007.05881.x
• EISSN: 1365-2958
• ISSN: 0950-382X
• Language: English
• Keywords: Mutation; Cell Polarity; Escherichia coli Proteins; Protein Transport; Chromosomes, Bacterial; Chromosome Segregation; Chromosomal Proteins, Non-Histone; Escherichia coli; Models, Genetic; Replication Origin