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Caspase cleavage of Ets-1 p51 generates fragments with transcriptional dominant-negative function.

Abstract:

Ets-1 is a transcription factor that plays an important role in various physiological and pathological processes, such as development, angiogenesis, apoptosis and tumour invasion. In the present study, we have demonstrated that Ets-1 p51, but not the spliced variant Ets-1 p42, is processed in a caspase-dependent manner in Jurkat T-leukaemia cells undergoing apoptosis, resulting in three C-terminal fragments Cp20, Cp17 and Cp14 and a N-terminal fragment, Np36. In vitro cleavage of Ets-1 p51 by...

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Publication status:
Published

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Publisher copy:
10.1042/bj20090877

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Biochemical journal More from this journal
Volume:
426
Issue:
2
Pages:
229-241
Publication date:
2010-03-01
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
Language:
English
Keywords:
Pubs id:
pubs:56487
UUID:
uuid:613cede7-f85a-4c01-b9f4-622557c007c0
Local pid:
pubs:56487
Source identifiers:
56487
Deposit date:
2012-12-19

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