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Adenoviral vector vaccination induces a conserved program of CD8+ T cell memory differentiation in mouse and man

Abstract:

Following exposure to vaccines, antigen-specific CD8+ T cell responses develop as long-term memory pools. Vaccine strategies based on adenoviral vectors, e.g., those developed for HCV, are able to induce and sustain substantial CD8+ T cell populations. How such populations evolve following vaccination remains to be defined at a transcriptional level. We addressed the transcriptional regulation of divergent CD8+ T cell memory pools induced by an adenovector encoding a model antigen (beta-galac...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2015.10.034

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Publisher:
Cell Press
Journal:
Cell Reports More from this journal
Volume:
13
Issue:
8
Pages:
1578-1588
Publication date:
2015-11-12
DOI:
ISSN:
2211-1247
Pubs id:
pubs:570051
UUID:
uuid:613b93e9-4ed8-4e9e-b2cd-09c5b07d3691
Local pid:
pubs:570051
Source identifiers:
570051
Deposit date:
2015-10-12

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