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Genome organization is a major component of gene expression control in response to stress and during the cell division cycle in trypanosomes

Abstract:

The trypanosome genome is characterized by RNA polymerase II-driven polycistronic transcription of protein-coding genes. Ten to hundreds of genes are co-transcribed from a single promoter; thus, selective regulation of individual genes via initiation is impossible. However, selective responses to external stimuli occur and post-transcriptional mechanisms are thought to account for all temporal gene expression patterns. We show that genes encoding mRNAs that are differentially regulated during...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1098/rsob.120033

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Publisher:
Royal Society Publisher's website
Journal:
Open Biology Journal website
Volume:
2
Issue:
4
Article number:
120033
Publication date:
2012-04-01
DOI:
EISSN:
2046-2441
ISSN:
2046-2441
Source identifiers:
312244
Language:
English
Keywords:
Pubs id:
pubs:312244
UUID:
uuid:6136a403-91db-4fb3-bd60-d6dd393c84f8
Local pid:
pubs:312244
Deposit date:
2013-03-20

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