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Journal article

Functional and structural characterization of the integrase from the prototype foamy virus.

Abstract:

Establishment of the stable provirus is an essential step in retroviral replication, orchestrated by integrase (IN), a virus-derived enzyme. Until now, available structural information was limited to the INs of human immunodeficiency virus type 1 (HIV-1), avian sarcoma virus (ASV) and their close orthologs from the Lentivirus and Alpharetrovirus genera. Here, we characterized the in vitro activity of the prototype foamy virus (PFV) IN from the Spumavirus genus and determined the three-dimensi...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gkn938

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Nucleic acids research More from this journal
Volume:
37
Issue:
1
Pages:
243-255
Publication date:
2009-01-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Language:
English
Keywords:
Pubs id:
pubs:7395
UUID:
uuid:6134b82e-f88c-4293-a46e-21d4ce762d01
Local pid:
pubs:7395
Source identifiers:
7395
Deposit date:
2012-12-19

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