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The cognitive role of the Globus Pallidus interna; Insights from disease states.

Abstract:

The motor symptoms of both Parkinson's disease and focal dystonia arise from dysfunction of the basal ganglia, and are improved by pallidotomy or deep brain stimulation of the Globus Pallidus interna (GPi). However, Parkinson's disease is associated with a greater degree of basal ganglia-dependent learning impairment than dystonia. We attempt to understand this observation in terms of a comparison of the electrophysiology of the output of the basal ganglia between the two conditions. We use t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00221-017-4905-8

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
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Publisher:
Springer Publisher's website
Journal:
Experimental Brain Research Journal website
Volume:
235
Issue:
5
Pages:
1455–1465
Publication date:
2017-02-01
Acceptance date:
2017-02-03
DOI:
ISSN:
1432-1106
Source identifiers:
684114
Language:
English
Keywords:
Pubs id:
pubs:684114
UUID:
uuid:61285bc6-0328-433a-954a-55f2005eb4b6
Local pid:
pubs:684114
Deposit date:
2017-03-07

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