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The cognitive role of the Globus Pallidus interna; Insights from disease states.

Abstract:

The motor symptoms of both Parkinson's disease and focal dystonia arise from dysfunction of the basal ganglia, and are improved by pallidotomy or deep brain stimulation of the Globus Pallidus interna (GPi). However, Parkinson's disease is associated with a greater degree of basal ganglia-dependent learning impairment than dystonia. We attempt to understand this observation in terms of a comparison of the electrophysiology of the output of the basal ganglia between the two conditions. We use t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00221-017-4905-8

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Department:
Oxford, MSD, Surgical Sciences
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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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Department:
Oxford, MSD, Clinical Neurosciences
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Department:
Oxford, MSD, Clinical Neurosciences
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Publisher:
Springer Publisher's website
Journal:
Experimental Brain Research Journal website
Volume:
235
Issue:
5
Pages:
1455–1465
Publication date:
2017-02-05
Acceptance date:
2017-02-03
DOI:
ISSN:
1432-1106
Pubs id:
pubs:684114
URN:
uri:61285bc6-0328-433a-954a-55f2005eb4b6
UUID:
uuid:61285bc6-0328-433a-954a-55f2005eb4b6
Local pid:
pubs:684114

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