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Gag-specific CD4+ T-cell responses are associated with virological control of paediatric HIV-1 infection.

Abstract:

HIV-specific Elispot responses were investigated in 57 antiretroviral therapy-naive children, of median age 9.9 years. CD8(+) T-cell responses were detected in 96% children; Nef was the immunodominant protein. Responses broadened over time, but there was no association between magnitude, breadth or specificity of response and viraemia. Gag-specific CD4(+) T-cell responses, detectable in 26% children, correlated inversely with viraemia (R = -0.43, P < 0.001), suggesting that preservation of...

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Publication status:
Published

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Journal:
AIDS (London, England) More from this journal
Volume:
25
Issue:
10
Pages:
1329-1331
Publication date:
2011-06-01
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
Language:
English
Keywords:
Pubs id:
pubs:190711
UUID:
uuid:612246e6-ced1-43a9-ae7f-24a17e1675f4
Local pid:
pubs:190711
Source identifiers:
190711
Deposit date:
2012-12-19

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