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Rapid and efficient differentiation of functional motor neurons from human iPSC for neural injury modelling

Abstract:

Primary rodent neurons and immortalised cell lines have overwhelmingly been used for in vitro studies of traumatic injury to peripheral and central neurons, but have some limitations of physiological accuracy. Motor neurons (MN) derived from human induced pluripotent stem cells (iPSCs) enable the generation of cell models with features relevant to human physiology. To facilitate this, it is desirable that MN protocols both rapidly and efficiently differentiate human iPSCs into electrophysiolo...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.scr.2018.09.006

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Oxford college:
Balliol College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Science
Oxford college:
St Hugh's College
Role:
Author
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Funding agency for:
Jerusalem, A
China Regenerative Medicine Limited More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Stem Cell Research Journal website
Volume:
32
Pages:
126-134
Publication date:
2018-09-26
Acceptance date:
2018-09-10
DOI:
EISSN:
1876-7753
ISSN:
1873-5061
Pubs id:
pubs:920126
URN:
uri:611d9e2c-e262-47b2-892b-7b606e24319c
UUID:
uuid:611d9e2c-e262-47b2-892b-7b606e24319c
Local pid:
pubs:920126

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