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The antiproliferative effect of mesenchymal stem cells is a fundamental property shared by all stromal cells.

Abstract:

Although it has been widely demonstrated that human mesenchymal stem cells exert potent immunosuppressive effects, there is little information as to whether more mature mesenchymal stromal cells (SC) share the same property. Accordingly, we set out to test the ability of SC from different human tissues to inhibit the proliferation of PBMC following polyclonal stimuli. Chondrocytes, as well as fibroblasts from synovial joints, lung, and skin, were used as a source of SC. Irrespective of their ...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.179.5.2824

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
179
Issue:
5
Pages:
2824-2831
Publication date:
2007-09-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:61196ab4-2ce1-4f90-a8a9-a32efd08c0e8
Source identifiers:
223514
Local pid:
pubs:223514

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