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Journal article

Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma.

Abstract:

Hypoxia and pH influence gene expression in tumours, and it is becoming increasingly clear that the pattern of genes expressed by a tumour determines its growth and survival characteristics. Hypoxia-inducible factor-1 (HIF-1) is a key mediator of the cellular response to hypoxia and high HIF-1 expression has been identified as a poor prognostic factor in tumours. Recently, we identified the tumour-associated carbonic anhydrases (CA), CA9 and CA12 as hypoxia-inducible in tumour cell lines. Fur...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6600796

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Journal:
British journal of cancer
Volume:
88
Issue:
7
Pages:
1065-1070
Publication date:
2003-04-05
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
URN:
uuid:6112e67e-6ef7-435e-bfd1-a2bd0c90c608
Source identifiers:
74276
Local pid:
pubs:74276

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